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Feb 21, 2008· EPA sought public input by asking for nominations of contaminants to consider for the CCL (71 FR 60704 (USEPA, 2006 b)) and incorporated these nominations in the three key steps already discussed. EPA also convened several expert panels for both chemicals and microbes to review, and provide input and comment, on the CCL 3 process and on a ...
----- OPPT ORIENTATION AGENDA DAY 2—April 8, 1994 9:00 an - 4:00 pm Room Number—WIC 3 North 9:00 - 9:05 Welcome HRT 9:05 - 9:15 GAME for Introductions BAD PROMOTING RISK REDUCTION (Cont.) 9:15 - 10:00 Risk Assessment CSRAD i 10:00 - 10:15 BREAK 10:15 - 10:45 Risk Management CCD 10:45 - 11:15 Source Reduction Review Project …
NTP. N. T. P. Toxicology and Carcinogenesis Studies of Chloroprene (CAS No. 126-99-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) US Department of Health and Human Services, Public Health Service, National Institutes of Health; Research Triangle Park, NC: 1998. (Technical Report Series No. 467). NIH Publication No. 98-3957.
OSHA Occupational Chemical Database. This chemical inventory is OSHA's premier one-stop shop for occupational chemical information. It compiles information from several government agencies and organizations. Information available on the pages includes: Chemical identification and physical properties. Exposure limits.
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Sep 30, 2019· Oral RfD Replaced on IRIS: Cumene; CASRN 98-82-8 (RfD changed) Inhalation RfC Added to IRIS: Cumene; CASRN 98-82-8; Carcinogenicity Assessment Added to IRIS: Cumene; CASRN 98-82-8; 15 July 1997 IRIS Pilot Project Toxicological Review Documents for Cumene and Tributyltin Oxide (TBTO) Available
Oct 27, 2014· NTP Toxicology and carcinogenesis studies of cumene (CAS No. 98-82-8) in F344/N rats and B6C3F1 mice (inhalation studies) Natl Toxicol Program Tech Rep Ser. 2009:1–200. [Google Scholar] NTP . NTP Historical Controls for NTP-2000 Diet. National Toxicology Program; Research Triangle Park, NC: 2013. [Google Scholar] NTP .
In 2011, between 100 000 and 1 000 000 kg of cumene (CAS RN 98-82-8) were reported to be manufactured in Canada, and the same quantity was imported into Canada. There were no reports of manufacture or import for 7, 12- dimethylbenz[a]anthracene (DMBA, CAS RN 57-97-6) above the reporting threshold of100 kg for the same year.
Mar 19, 2021· The current Proposition 65 list is dated March 19, 2021. Current Proposition 65 List. The current Proposition 65 list is available on-line below, as a pdf or Excel download or through .The Excel document also includes the listing mechanism for each chemical listing and the safe harbor level, if one has been adopted.
In 1992 (the year PDUFA was passed), 26 NDAs were approved, requiring on average 29.9 months for data review; while in 1996, 53 new drug (or biological) products were approved, each requiring an average of 17.8 months of review time. PDUFA was successful in decreasing review times, but has not really streamlined the procedures.
Mar 10, 2020· To support the third Six-Year Review of regulated contaminants (USEPA, 2016c), the EPA issued an ICR to collect compliance monitoring data from PWSs for 2006-2011. After issuing the ICR, 46 states and 8 other primacy agencies provided compliance monitoring data.
NTP (2006). TR534 Toxicology and Carcinogenesis Studies of Divinylbenzene (CAS No. ) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). Natl Toxicol Program Tech Rep Ser. 2006 Nov; 534:1-294. NTP (2009). TR542 Toxicology and Carcinogenesis Studies of Cumene (CAS No. 98-82-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies).
CHRONIC CUMENE Time Report Reqsted: 15:28:27 Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 98-82-8 First Dose M/F: 06/11/01 / 06/11/01 Species/Strain: MICE /B6C3F1 Pathologist: ... P04: Neoplasms by Individual Animal for Mice (97003-08) 7.2MB
New Window. Using a structure estimation method based on molecular connectivity indices (1), the Koc of dicumyl peroxide can be estimated to be 322,900 (SRC). According to a classification scheme (2), this estimated Koc value suggests that dicumyl peroxide is …
Oct 02, 2019· Chemical Information Profile for 1-Chloro-4-(trifluoromethyl)-benzene [CAS No. 98-56-6]; Supporting Nomination for Toxicological Evaluation by the National Toxicology Program. National Toxicology Program, National Institute of Environmental Health Sciences, June 2009.
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National Toxicology Program (NTP) 1998 Toxicology and Carcinogenesis Studies of Chloroprene (CAS no. 126-99-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). Technical Report Series no. 467. Technical Report Series no. 467.
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The National Toxicology Program has added seven new substances to its 14th Report on Carcinogens, bringing the total number in this congressionally mandated report to 248. The latest additions are the chemical trichloroethylene; cobalt metal and compounds that release cobalt ions in vivo; and five viruses, including HIV-1. ©2017 American ...
Report of the Advisory Group to Recommend Priorities for the IARC Monographs during 2020–2024
Cumene Profile a) Commercial Use; Cumene is a high volume chemical, ranked thirtieth (4.00 billion Ib.) according to C&EN's Top 50 list. It is produced at 22 manufacturing sites* with 32% of the sites and 52% of the total production volume reporting in the one hundred million to five hundred million (PI)** range.
Classification 10-minute 30-minute 1-hour 4-hour 8-hour Endpoint (Reference) AEGL–2 720 ppm 720 ppm 570 ppm 360 ppm 180 ppm 4-hr BMCL05 in rats (Tansy et al., 1980; NTP, 1986) Styrene (CAS No. 80-62-6) Staff Scientist: Jens-Uwe Voss, Chemrisk, Germany Chemical Manager: Lynn Beasley, U.S. EPA
Toxicology and Carcinogenesis Studies of Cumene (CAS No. 98-82-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). Natl Toxicol Program Tech Rep Ser 2009;542;NIH 09-5885. Hong HHL, Ton TVT, Kim Y, Wakamatsu N, Clayton NP, Chan PC et al. Genetic Alterations in K-ras and p53 Cancer Genes in Lung Neoplasms from B6C3F1 Mice Exposed to Cumene.
butadiene, styrene and benzene among workers in the synthetic rubber National Toxicology Program (NTP). (1998). Toxicology and Carcinogenesis industry. Toxicology 113, 190–202. Studies of Chloroprene (CAS no. 126-99-8) in F344/N Rats and B6C3F1 Malkinson, A. M. (1992).
Jul 22, 2017· In 2011, between 100 000 and 1 000 000 kg of cumene (CAS RN 98-82-8) were reported to be manufactured in Canada, and the same quantity was imported into Canada. There were no reports of manufacture or import for 7,12-dimethylbenz[a]anthracene (DMBA, CAS RN 57-97-6) above the reporting threshold of 100 kg for the same year.
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Those nominations not selected for review are returned to the original nominator who is invited to resubmit the nomination with additional information such as new data, exposure information, etc. that justifies a formal review. The NTP may defer or terminate the review of a proposed nomination at any time if relevant information becomes ...